Symbol
Name
ID

Ctsl
cathepsin L
MGI:88564

Phenotype annotations related to immune system

Darker colors indicate more annotations

Mouse Phenotypes

salivary gland inflammation

abnormal thymus morphology

abnormal thymus lobule morphology

enlarged thymus cortex

abnormal thymus corticomedullary boundary morphology

thymus atrophy

insulitis

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal leukocyte cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

increased alpha-beta T cell number

increased regulatory T cell number

decreased osteoclast cell number

abnormal CD8-positive, alpha beta T cell morphology

abnormal osteoclast physiology

abnormal immune system organ morphology

abnormal lymph node morphology

abnormal lymph node cortex morphology

dilated lymph node medullary sinus

enlarged lymph nodes

lymph node hyperplasia

lymph node inflammation

decreased susceptibility to autoimmune diabetes

granulomatous inflammation

increased inflammatory response

folliculitis

liver inflammation

dermatitis

Availability

Mouse Genotype

Ctsl^m1Btlr/Ctsl^m1Btlr

Ctsl^nkt/Ctsl^nkt

Ctsl^tm1.2Thre/Ctsl^tm1.2Thre

Ctsl^tm1Alpk/Ctsl^tm1Alpk

Ctsl^tm1Cptr/Ctsl^tm1Cptr

Ctsl^tm1Cptr/Ctsl⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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